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AIR synthetase is the fifth enzyme in the ''de novo'' synthesis of purine nucleotides. It catalyzes the reaction to form 5-aminoimidizole ribonucleotide (AIR) from formylglycinamidine-ribonucleotide FGAM. This reaction closes the ring and produces a 5-membered imidazole ring of the purine nucleus (AIR): 480px ATP + 2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine ADP + 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + phosphate + AIR synthetase catalyzes the transfer of the oxygen of the formyl group to phosphate. It is a sequential mechanism in which ATP binds first to the enzyme and ADP is released last. This enzyme hydrolyzes ATP to activate the oxygen of the amide in order to carry out a nucleophilic attack by a nitrogen. In humans and many other organisms, this enzyme is contained within the trifunctional purine biosynthetic protein adenosine-3 polypeptide. == Nomenclature == The systematic name of this enzyme class is 2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming). Other names in common use include: * AIR synthetase, * 5'-aminoimidazole ribonucleotide synthetase, * 2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming), * phosphoribosylaminoimidazole synthetase, and * phosphoribosylformylglycinamidine cyclo-ligase. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「AIR synthetase (FGAM cyclase)」の詳細全文を読む スポンサード リンク
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